Recent Developments At Burnham Institute For Medical Research, November 2009
New antibiotics for methicillin-resistant Staphylococcus aureus (MRSA) and other pesky bacteria. Andrei Osterman and collaborators have used comparisons of bacterial genomes to identify new targets for antibiotics and produced first-generation chemical inhibitors of a class of bacterial enzymes, called NadDs (nicotinate mononucleotide adenylyltransferases). Described in a recent article in Chemistry & Biology (Cell Press), the team, led by Dr.