Archive for the ‘Immune System / Vaccines’ Category

Celiac Disease: Pinpointing Immune System Disturbances

New research has identified four aspects of immune system disturbance which lead to the development of coeliac disease. Nearly 40 different inherited risk factors which predispose to the disease have now been identified...

Efficacy Of Flu Vaccine Drastically Reduced For RA Patients Treated With Rituximab

Rheumatoid arthritis (RA) patients are partially protected by the influenza vaccine 6 - 10 months after treatment with rituximab. Researchers determined that while the flu vaccine is safe, it is ineffective for RA patients in the first 6 months following rituximab treatment...

Immune Responses To Tetanus Vaccine Unchanged For RA Patients On Rituximab

Researchers from Johns Hopkins University determined that immune responses to the tetanus vaccine were not changed when rituximab in combination with methotrexate (MTX) was compared with MTX alone in patients with rheumatoid arthritis (RA). Responses to a pneumococcal vaccination (Pneumovax® pneumonia vaccine), however, were reduced in RA patients with rituximab...

Compound Created That Boosts Anti-Inflammatory Fat Levels

UC Irvine pharmacology researchers have discovered a way to boost levels of a natural body fat that helps decrease inflammation, pointing to possible new treatments for allergies, illnesses and injuries related to the immune system...

Compound Created That Boosts Anti-Inflammatory Fat Levels

UC Irvine pharmacology researchers have discovered a way to boost levels of a natural body fat that helps decrease inflammation, pointing to possible new treatments for allergies, illnesses and injuries related to the immune system...

New Human Immunology Research Awards To Help Fight Emerging Infectious Diseases Announced By NIAID

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has awarded approximately $208 million to two programs that support research to better understand the human immune response to emerging and re-emerging infectious diseases, including those that may be introduced into a community through acts of bioterrorism...

New Human Immunology Research Awards To Help Fight Emerging Infectious Diseases Announced By NIAID

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has awarded approximately $208 million to two programs that support research to better understand the human immune response to emerging and re-emerging infectious diseases, including those that may be introduced into a community through acts of bioterrorism...

Common Pain Relievers May Dilute Power Of Flu Shots

With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers -- Advil, Tylenol, aspirin -- at the time of injection may blunt the effect of the shot and have a negative effect on the immune system. Richard P. Phipps, Ph.D.

Progress Made On Group B Streptococcus Vaccine

WHAT: Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have completed a Phase II clinical study that indicates a vaccine to prevent Group B Streptococcus (GBS) infection is possible. GBS is the most common cause of sepsis and meningitis in newborns in the United States, according to the Centers for Disease Control and Prevention (CDC).

Biomedical Research Centre Searches For Immunological Biomarkers

Persistent inflammation and the activation of the immune system is the key pathological mechanism affecting many long-term conditions, such as rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn's disease and is the predominant mechanism underlying organ transplant rejection. But the molecular and cellular processes triggering these inflammatory and immune responses remain little understood.

HPV Vaccination: Including Boys In The Programs Would Not Be Cost-Effective

New research published on bmj.com today reports that if boys were included in human papillomavirus (HPV) vaccination programs of pre-adolescent girls, it would not be cost-effective. It is probable that the costs of vaccinating boys will outweigh the added health benefits. It has been consistently exposed in prior studies that HPV vaccination of pre-adolescent (12 year-old) girls provides good value for money.

Autoimmunity: Visionary Concept Earns La Jolla Institute Scientist Prestigious NIH Pioneer Award

A scientist at the La Jolla Institute for Allergy & Immunology has received one of the National Institutes of Health (NIH)'s top awards -- the 2009 NIH Director's Pioneer Award. The prestigious prize carries with it funding for total costs of up to $4.7 million over five years, and is designed to support the work of exceptionally creative scientists, whose novel proposals offer the potential to make extraordinary contributions to human health. Hilde Cheroutre, Ph.D.

British Prime Minister To Unveil $1B Effort To Improve Health Systems In Developing Countries

During the U.N. General Assembly meeting in New York, British Prime Minister Gordon Brown on Wednesday is scheduled to announce that Britain is teaming up with Norway, the Netherlands and Australia to invest $1 billion to strengthen the health systems in developing countries, the

Critical Molecule To Celiac Disease, Possibly Other Autoimmune Disorders, Pinpointed By UM Scientists

It was nine years ago that University of Maryland School of Medicine researchers discovered that a mysterious human protein called zonulin played a critical role in celiac disease and other autoimmune disorders, such as multiple sclerosis and diabetes. Now, scientists have solved the mystery of zonulin's identity, putting a face to the name, in a sense. Scientists led by Alessio Fasano, M.D., have identified zonulin as a molecule in the human body called haptoglobin 2 precursor.

Using Lyme Disease As A Model, MU Researchers Find Inflammatory Disease Treatments Will Improve Through The Use Of Lipidomics

According to the National Center for Chronic Disease Prevention and Health Promotion, 46 million Americans have arthritis. Many of these people take over-the-counter anti-inflammatory medications that block production of certain molecules, known as bioactive lipids, to reduce pain and swelling. Yet, the role of these lipids is not yet understood completely, and medications may have adverse side effects.

Taking The Sting Out Of Shots With Painless ‘Microneedle’ Patch

Good news for people fearful of needles and squeamish of shots: Scientists at the 238th National Meeting of the American Chemical Society report the design of a painless patch that may someday render hypodermic needles - as well as annual flu shots - a thing of the past. Lined with tiny "microneedles," these patches could make treatment of diabetes and a wide range of other diseases safer, more effective and less painful.

Sun Exposure May Trigger Certain Autoimmune Diseases In Women

Ultraviolet (UV) radiation from sunlight may be associated with the development of certain autoimmune diseases, particularly in women, according to a study by researchers at the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health.

Seminal Finding Has Major Implications For The Development Of New And Better Vaccines

A research team led by the La Jolla Institute for Allergy & Immunology has identified the specific gene which triggers the body to produce disease-fighting antibodies -- a seminal finding that clarifies the exact molecular steps taken by the body to mount an antibody defense against viruses and other pathogens. The finding, published online today in the prestigious journal Science, has major implications for the development of new and more effective vaccines.

Funxional Successfully Completes Initial Clinical Trial Of FX125L, An Anti-Inflammatory Drug With A Novel Mechanism Of Action

Funxional Therapeutics Ltd (Funxional) has announced the successful completion of the first Phase I study with FX125L, an orally available small molecule which belongs to a new therapeutic class named Broad Spectrum Chemokine Inhibitors (BSCIs). The Phase I, single ascending dose study was conducted in the United States. FX125L was well tolerated at all doses studied and no serious adverse events or subject withdrawals were observed.

Trapping Immune Cells In The Uterus Prevents Anti-fetal Immunity

Why the immune system of a pregnant woman does not attack her developing fetus is one of most remarkable features of pregnancy, and several underlying mechanisms have been described. However, Adrian Erlebacher and colleagues, at the New York University School of Medicine, New York, have now identified a new mechanism to explain why the mouse maternal immune system does not attack the fetuses.

Also In Global Health News: Measles Vaccine; Drug Discovery; Child, Maternal Health; HIV/AIDS Programs

Measles Vaccine Campaign Underway In Namibia Measles "continues to be the biggest killer of under-five children" in Namibia and a national campaign to vaccinate children is currently underway, reports Informante. Children will also receive polio vaccines and vitamin A supplements.